Quino's daily newspaper strip Mafalda was his most successful cartooning venture. Mafalda ran from 1964 to 1973. The comic was translated into more than 30 languages. However, it never received much of an audience in the English-speaking world, perhaps because, as Quino put it, the strip was "too Latin American.
"In 1976, the character Mafalda was chosen by UNICEF to be a spokesperson for the Convention on the Rights of the Child. Mafalda is still translated in book collections. Argentine director Daniel Mallo translated 260 Mafalda strips into 90-second cartoons that aired in Argentina, starting in 1972.